Answer :
That is a good question to ask if you are planning a trip. A good source is the NTSB website. They have tables full of Statistics so I will try to summarize it. It is also good info on crash investigations and has reported findings that make for some good information—although it might scare some people away from flying.
Scheduled US Airlines Stats for 2006
25 Accidents with 2 fatal accidents out of 11,200,000 flights.
Total 50 fatalies
Accident rate per 100,000 is 0.223 or 0.018 for those with fatalies.